Drug Assessments

This page and the drug assessments search provide access to Sentinel assessments that have been conducted by the U.S. Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER).

CDER ensures that safe and effective drugs are available to American consumers. CDER evaluates safety throughout the drug life cycle. CDER also maintains a system of postmarketing surveillance and risk assessment programs.

CDER’s Office of Surveillance and Epidemiology manages the Sentinel Initiative. Sentinel is an important component of CDER’s postmarketing safety system. CDER uses Sentinel to proactively assess the safety of drugs under real-world conditions. This closely reflects patient care in the United States. This capability enhances drug safety monitoring. It also allows CDER to systematically evaluate safety signals identified during premarket trials. CDER also evaluates safety signals that emerge after products reach the market.

Sentinel assessments use automated surveillance tools. These same tools support FDA’s Active Risk Identification & Analysis System (ARIA). This approach improves the efficiency of FDA monitoring. It also ensures patient privacy through the use of the Sentinel Distributed Database.

CDER uses results to evaluate safety signals. Sentinel assessments complement existing surveillance systems. Existing surveillance systems include FDA’s Adverse Event Reporting System (FAERS). CDER reviews the results, balancing the strengths and limitations of each data source. In doing this, they can make the most informed regulatory decisions possible.

The search options below can be used to find materials based on medical product, safety outcome, and the following study types:

  • Exploratory Analyses
    • Characterize the rates of health outcomes, examine medical product use, and explore the feasibility of more detailed evaluations.
  • Safety Analyses
    • Build on exploratory work and formally evaluate medical product-outcome associations using more advanced study designs and statistical methods to control for confounding.

Search Drug Assessments

Title Medical Product Outcomes Date
Factors Related to the Assignment of Sodium Glucose Cotransporter-2 Inhibitors (SGLT-2i) versus Dipeptidyl Peptidase-4 Inhibitors (DPP-4i)
Exploratory Analyses
sodium-glucose cotransporter-2 (SGLT-2) inhibitor
factors for treatment assignment
09/16/2020
Frequency of Percutaneous Transluminal Septal Myocardial Ablation (PTSMA) and Estimated Incidence Rates of Post-PTSMA Cardiovascular Outcomes: A Descriptive Analysis
Exploratory Analyses
percutaneous transluminal septal myocardial ablation
09/16/2020
Wrong Frequency Errors with Low Dose Oral Methotrexate
Safety Analyses
methotrexate
09/16/2020
Acute Myocardial Infarction and Heart Failure following Saxagliptin or Sitagliptin Use: A Propensity Score Matched Analysis
Safety Analyses
saxagliptin, sitagliptin, pioglitazone, long-acting insulin, second-generation sulfonylurea
acute myocardial infarction (AMI)
heart failure
09/16/2020
Stroke, Intracranial Hemorrhage, and Bleeding following Dabigatran, Rivaroxaban, and Apixaban Use in Patients Aged 65 or Older: A Propensity Score Matched Analysis
Exploratory Analyses
dabigatran, rivaroxaban, apixaban
bleeding event
intracranial hemorrhage
stroke
09/15/2020
Cutaneous Small-Vessel Vasculitis following Non-Vitamin K Antagonist Oral Anticoagulants (NOACs), Warfarin, or Allopurinol Use in Patients with Atrial Fibrillation: A Descriptive Analysis
Exploratory Analyses
warfarin, allopurinol, non-vitamin K antagonist oral anticoagulants
cutaneous small vessel vasculitis
09/14/2020
Same Day Seizures following Gadolinium Based Contrast Agents: A Self-Controlled Risk Interval Analysis
Safety Analyses
gadolinium-based contrast agent (GBCA)
seizure
09/11/2020
Ranitidine Drug Utilization Patterns
Exploratory Analyses
ranitidine
09/03/2020
Intravenous (IV) Iron Utilization Among Pregnant Women
Exploratory Analyses
intravenous (IV) iron
09/02/2020
Algorithms to Estimate Start of Pregnancy Using In-Vitro Fertilization (IVF), Intrauterine Insemination (IUI), and Select Prenatal Tests among Pregnancies Resulting in a Live-Born Delivery
Exploratory Analyses
08/28/2020
Mini-Sentinel: Availability of International Normalized Ratio (INR) Laboratory Test Values and INR Test Procedures among New Warfarin Users
Exploratory Analyses
warfarin
08/27/2020
Spironolactone Use in Patients with Reduced Ejection Fraction Heart Failure (HFrEF) or Preserved Ejection Fraction Heart Failure (HFpEF)
Exploratory Analyses
spironolactone
08/26/2020
Sacubitril/​Valsartan, Angiotensin-Converting Enzyme (ACE) Inhibitors, and Other Angiotensin II Receptor Blockers (ARBs) Use in Patients with Heart Failure
Exploratory Analyses
sacubitril/​valsartan, angiotensin-converting enzyme (ACE) inhibitor, angiotensin II receptor blocker (ARB)
08/26/2020
Mini-Sentinel: Switching Between Generic and Brand Clonazepam
Exploratory Analyses
clonazepam
08/25/2020
Incidence of Severe Uterine Bleed Following Novel Oral Anticoagulants Use: A Descriptive Analysis
Exploratory Analyses
rivaroxaban, apixaban, dabigatran, warfarin
severe uterine bleed
08/24/2020
Glaucoma, Cataracts, Diminished Visual Acuity, and Nasal Septal Perforation following Mometasone Sinus Implant Use in Patients with Nasal Polyposis: A Descriptive Analysis
Safety Analyses
cataracts
diminished visual acuity
glaucoma
nasal septal perforation
08/05/2020
Risk of Congenital Cardiac Malformations Following Armodafinil or Modafinil Use: A Propensity Score Matched Analysis
Safety Analyses
modafinil, armodafinil
congenital cardiac malformations
07/30/2020
Hypertension in Pediatric Patients: A Descriptive Analysis
Exploratory Analyses
hypertension
07/23/2020
Use of Typical and Atypical Antipsychotics Among Infants
Exploratory Analyses
typical antipsychotic, atypical antipsychotic, antipsychotic
05/20/2020
Characterization of SGLT-2 Inhibitor Users in the Patient-Centered Clinical Research Network (PCORnet)
Exploratory Analyses
sodium-glucose cotransporter-2 (SGLT-2) inhibitor, sitagliptin
03/19/2020
Non-Melanoma Skin Cancer following Hydrochlorothiazide Use: A Propensity Score Matched Analysis
Safety Analyses
hydrochlorothiazide (HCTZ)
non-melanoma skin cancer
03/05/2020
Total Enrollment with Medical and Drug Coverage
Exploratory Analyses
02/19/2020
Trends in Penicillin Allergy Testing
Exploratory Analyses
penicillin allergy test
01/30/2020
Time Until Guillain-Barré Syndrome or Bell's Palsy Diagnosis following Initiation of Checkpoint Inhibitor Treatment
Exploratory Analyses
ipilimumab, nivolumab, pembrolizumab, atezolizumab, avelumab, durvalumab
Bell’s palsy
Guillain-Barré syndrome
01/24/2020
Prenatal Tests in Women with Potential Stillbirths
Exploratory Analyses
prenatal tests
stillbirth
01/24/2020
Concurrent Use of Ticagrelor with Atorvastatin or Rosuvastatin
Exploratory Analyses
ticagrelor, atorvastatin, rosuvastatin
01/24/2020
Duration of Follow-up for Individuals with Chronic Conditions
Exploratory Analyses
Alzheimer's disease
acquired hypothyroidism
acute myocardial infarction (AMI)
anemia
asthma
atrial fibrillation
benign prostatic hyperplasia
breast cancer
bronchiectasis
chronic conditions
chronic kidney disease (CKD)
chronic obstructive pulmonary disease
colorectal cancer
depression
diabetes
endometrial cancer
glaucoma
heart failure
hyperlipidemia
hypertension
ischemic heart disease
lung cancer
osteoarthritis
osteoporosis
prostate cancer
rheumatoid arthritis
stroke
transient ischemic attack (TIA)
01/23/2020
Use of Metoclopramide among Patients with Diabetic Gastroparesis and Type 2 Diabetes
Exploratory Analyses
metoclopramide HCL
diabetic gastroparesis
type 2 diabetes mellitus
01/13/2020
Hydroxyurea Use in Patients with Sickle Cell Anemia
Exploratory Analyses
hydroxyurea
sickle cell anemia
use by indication
01/07/2020
Mini-Sentinel: Summary of Antidiabetic Agent Use During Pregnancy
Exploratory Analyses
dipeptidyl peptidase-4 (DPP-4) inhibitor, sulfonylurea, thiazolidinedione, alpha-glucosidase inhibitor, amylin analog, biguanide, glucagon-like peptide-1 (GLP-1) receptor agonist, meglitinide analog, injectable insulin
exposure in pregnancy
01/02/2020
Epidemiology of Pediatric Respiratory Syncytial Virus-Associated Illness in FDA’s Sentinel System
Exploratory Analyses
respiratory syncytial virus (RSV)
respiratory syncytial virus-associated illness
12/06/2019
Estimating Optimal Quantities for Initial Opioid Analgesic Prescriptions for Acute Pain Conditions Presenting to Surgical Settings
Exploratory Analyses
opioid analgesic
drug refill probability
11/20/2019
Respiratory Syncytial Virus in a Pediatric Population
Exploratory Analyses
respiratory syncytial virus (RSV)
11/19/2019
Hydroxyprogesterone Caproate and Progesterone Use During Pregnancy
Exploratory Analyses
hydroxyprogesterone caproate, progesterone
exposure in pregnancy
10/29/2019
Neuropsychiatric Events Following Montelukast Use: A Propensity Score Matched Analysis
Safety Analyses
montelukast
inpatient depressive disorder
outpatient depressive disorder
self-harm
suicide
09/27/2019
Multiple Sclerosis Relapses among Copaxone, Glatopa, Gilenya, and Glatiramer Users
Exploratory Analyses
Copaxone, Glatopa, Gilenya, glatiramer
multiple sclerosis relapse
09/17/2019
Cutaneous Small Vessel Vasculitis and Acute Kidney Injury Following Direct-Acting Oral Anticoagulant Use
Exploratory Analyses
direct-acting oral anticoagulant
acute kidney injury
cutaneous small vessel vasculitis
09/16/2019
Sinus Stents with Mometasone and Diminished Visual Acuity
Safety Analyses
sinus stent, mometasone, intranasal steroid, oral steroid
blindness
cataract surgery
cataracts
diminished visual acuity
glaucoma
09/12/2019
Non-Melanoma Skin Cancer following Hydrochlorothiazide Use
Exploratory Analyses
hydrochlorothiazide (HCTZ), chlorothiazide (CTZ), bendroflumethiazide (BFMTZ)
non-melanoma skin cancer
09/12/2019
Use of Angiotensin-Converting Enzyme (ACE) Inhibitors and Angiotensin Receptor Blockers (ARB) in a Pediatric Population
Exploratory Analyses
angiotensin-converting enzyme (ACE) inhibitor, angiotensin receptor blocker
08/22/2019
Utilization Patterns of Qsymia (Phentermine/​Topiramate)
Exploratory Analyses
Qsymia, phentermine/​topiramate, phentermine HCl, topiramate
08/07/2019
Use of Higher Dosage Strength Oral and Transmucosal Opioid Analgesics
Exploratory Analyses
opioid analgesic, transdermal opioid analgesic, transmucosal opioid analgesic, oral opioid analgesic, lower dosage strength opioid analgesic, higher dosage strength opioid analgesic
07/31/2019
Osteoporotic Fractures Following Lupron Depot-PED Use: A Multiple Factor Matched Analysis
Safety Analyses
Lupron Depot-PED
fracture
hip replacement
osteoporotic fracture
temporomandibular joint replacement
07/02/2019
Use of Korlym and Mifeprex (Mifepristone)
Exploratory Analyses
mifepristone, Mifeprex, Korlym
06/24/2019
Antiemetic Use During Pregnancy
Exploratory Analyses
metoclopramide HCL, ondansetron, doxylamine, succinate/​pyridoxine HCl, granisetron, netupitant/​palonosetron HCl, palonosetron, prochlorperazine, promethazine HCl
exposure in pregnancy
06/24/2019
Use of Valsartan, Angiotensin II Receptor Blockers (ARB), and Angiotensin-Converting Enzyme (ACE) Inhibitors
Exploratory Analyses
valsartan, angiotensin-converting enzyme (ACE) inhibitor, angiotensin II receptor blocker (ARB), candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, azilsartan medoxomil
06/05/2019
New Users of Oral Bisphosphonates
Exploratory Analyses
bisphosphonate
05/08/2019
Neuropsychiatric Events following Montelukast Use
Exploratory Analyses
montelukast, zafirlukast, inhaled corticosteroid, nasal corticosteroid
neuropsychiatric event
psychotropic medication use
suicide
04/22/2019
Duration of Use Among New Users of Hydrochlorothiazide (HCTZ), Angiotensin-Converting Enzyme Inhibitors (ACEIs), and Angiotensin II Receptor Blockers (ARBs)
Exploratory Analyses
angiotensin-converting enzyme (ACE) inhibitor, angiotensin II receptor blocker (ARB), hydrochlorothiazide (HCTZ)
04/19/2019
Severe Uterine Bleed Following Novel Oral Anticoagulants Use: A Propensity Score Analysis
Safety Analyses
novel oral anticoagulant (NOAC), rivaroxaban, dabigatran, apixaban, warfarin
severe uterine bleed
04/18/2019
Lupron Depot-PED Use Among Patients with Central Precocious Puberty
Exploratory Analyses
Lupron Depot-PED
central precocious puberty
04/15/2019
Gadolinium-Based Contrast Agents (GBCAs) Use in Pregnancy
Safety Analyses
gadolinium-based contrast agent (GBCA)
exposure in pregnancy
04/04/2019
Duration of Follow-Up and Treatment for Non-Insulin Antidiabetic Drugs
Exploratory Analyses
non-insulin antidiabetics
04/02/2019
Dolutegravir Use During Pregnancy
Exploratory Analyses
dolutegravir
exposure in pregnancy
03/28/2019
Acute Myocardial Infarction and Stroke Among Patients with Testosterone-Related Indications
Exploratory Analyses
testosterone
acute myocardial infarction (AMI)
stroke
03/25/2019
Brintellix and Brilinta Medication Errors due to Name Confusion
Exploratory Analyses
Brintellix, Brilinta
medication error
03/24/2019
Characteristics of Gout Patients and Use of Urate-Lowering Therapies
Safety Analyses
urate-lowering therapies
gout
03/22/2019
Stroke, Gastrointestinal Bleeding, and Intracranial Hemorrhage Following Apixaban or Warfarin Use in Patients with Non-Valvular Atrial Fibrillation: A Propensity Score Matched Analysis
Safety Analyses
apixaban
gastrointestinal (GI) bleed
intracranial hemorrhage
stroke
02/15/2019
Optimal Initial Length of Opioid Prescription
Exploratory Analyses
opioid analgesic
02/01/2019
Seizure Following Ranolazine Use
Safety Analyses
ranolazine, Ranexa
seizure
01/03/2019
Use of Multiple Sclerosis Drugs Among Pregnant Women
Exploratory Analyses
dimethyl fumarate, dalfampridine, fingolimod, glatiramer acetate, interferon beta-1A, interferon beta-1A/​albumin, interferon beta-1B, peginterferon beta-1a, teriflunomide, alemtuzumab, natalizumab, daclizumab, mitoxantrone
pregnancy
12/06/2018
Pulmonary Arterial Hypertension and Interstitial Lung Disease Events Among Interleukin Inhibitor Users
Exploratory Analyses
interleukin-1/-6 inhibitor
interstitial lung disease
pulmonary arterial hypertension
12/03/2018
Duration of Use for Teriparatide
Exploratory Analyses
teriparatide
11/29/2018
Quantifying Prevalence and Mortality Associated with Neonatal Enteroviral Sepsis (NES) Using Inpatient Data in FDA’s Sentinel System
Exploratory Analyses
neonatal enteroviral sepsis (NES)
11/27/2018
COPD, Asthma, and Respiratory Disease Effectiveness (CARE) For 21st Century Cures: Feasibility Assessments for Comparative Effectiveness Studies
Exploratory Analyses
asthma
chronic obstructive pulmonary disease
11/06/2018
Counts and Proportions of New Users of Fentanyl Transdermal System with Evidence of Prior Opioid Tolerance
Exploratory Analyses
fentanyl transdermal system
11/06/2018
Phosphodiesterase Type 5 (PDE-5) Inhibitor Utilization Among Women
Exploratory Analyses
phosphodiesterase type 5 (PDE5) inhibitor
10/12/2018
Sofosbuvir and Amiodarone Use and Bradycardia or Pacemaker Insertion
Exploratory Analyses
sofosbuvir, amiodarone
bradycardia
pacemaker insertion
08/29/2018
Algorithms Evaluating Dabigatran Use and Acute Myocardial Infarction Compared with Warfarin
Exploratory Analyses
dabigatran, warfarin
acute myocardial infarction (AMI)
08/23/2018
Use of Dabigatran and Intracranial Hemorrhage, Gastrointestinal Hemorrhage, Ischemic Stroke, and Acute Myocardial Infarction
Safety Analyses
dabigatran
acute myocardial infarction (AMI)
gastrointestinal hemorrhage
intracranial hemorrhage
ischemic stroke
08/17/2018
New Pediatric Users of Leuprolide Acetate Depot
Exploratory Analyses
leuprolide acetate depot
08/17/2018
Prevalence and Incidence of Progressive Multifocal Leukoencephalopathy (PML), Clostridium Difficile, and Cytomegalovirus (CMV) Diagnoses
Exploratory Analyses
clostridium difficile
cytomegalovirus (CMV)
progressive multifocal leukoencephalopathy (PML)
06/04/2018
Incident Use of Selective Serotonin Reuptake Inhibitor Antidepressants
Exploratory Analyses
selective serotonin reuptake inhibitor (SSRI)
05/21/2018
Identifying Suicide Codes in the Sentinel Distributed Database (SDD)
Exploratory Analyses
suicide
04/24/2018
Clostridium difficile Infection Following Use of Vancomycin, Fidaxomicin, or Metronidzaole
Exploratory Analyses
vancomycin, fidaxomicin, metronidazole
clostridium difficile
04/03/2018
Availability of International Normalized Ratio (INR) Laboratory Test Values and Test Procedures Among Warfarin Users
Exploratory Analyses
warfarin
04/03/2018
Warfarin Use Followed by International Normalized Ratio (INR) Lab Codes
Exploratory Analyses
warfarin
04/02/2018
Top Ten Causes of Death
Exploratory Analyses
03/29/2018
Prevalent and Incident Use of Fingolimod
Exploratory Analyses
fingolimod
03/28/2018
Risk of Acute Myocardial Infarction and Stroke among Carbidopa/​Levodopa, Entacapone, and Carbidopa/​Levodopa/​Entacapone Users
Exploratory Analyses
entacapone, carbidopa/​levodopa, carbidopa/​levodopa/​entacapone (Stalevo)
03/27/2018
Prevalence and Incident Use of Promethazine
Exploratory Analyses
promethazine, promethazine/​codeine, promethazine/​phenylephrine/​codeine
03/26/2018
Use of Clonazepam
Exploratory Analyses
clonazepam
03/26/2018
Diagnosis of Agranulocytosis Following New Use of Anti-epileptic Drugs, Clozapine, and Olanzapine
Exploratory Analyses
carbamazepine, levetiracetam, lamotrigine, topiramate, clozapine, olanzapine, ofatumumab
agranulocytosis
03/21/2018
Counts and Prevalence of Alendronate, Risedronate, Ibandronate, and Zolendronate
Exploratory Analyses
ibandronate sodium, denosumab, alendronate sodium, alendronate sodium/​vitamin d3, risedronate sodium/​calcium carbonate, risedronate sodium, zoledronic acid, zoledronic acid/​mannitol and water, raloxifene HCL, calcitonin, salmon, synthetic, bandronate sodium, calcitonin salmon, teriparatide, zoledroniccid zometa, zoledroniccid reclast, zoledronic acid reclast
03/19/2018
Counts and Prevalence of Linezolid and Vancomycin
Exploratory Analyses
vancomycin, linezolid
03/19/2018
Use of Atrial Fibrillation Drugs
Exploratory Analyses
dofetilide, sotalol HCL
03/16/2018
Concomitancy and Indications for Idelalisib Use
Exploratory Analyses
bendamustine, bortezomib, chlorambucil, cyclophosphamide, doxorubicin, ibrutinib, idelalisib, lenalidomide, obinutuzumab, ofatumumab, prednisone, rituximab, vincristine, ibritumomab
03/13/2018
Incident Use of Hepatitis C Virus (HCV) Drugs
Exploratory Analyses
boceprevir, telaprevir, simeprevir sodium, ledipasivir/​sofosbuvir, sofosbuvir
03/13/2018
Prevalent and Incident Use of Generic Name Kinase Inhibitors
Exploratory Analyses
afatinib dimaleate, axitinib, cabozantinib s-malate, ceritinib, dabrafenib mesylate, erlotinib HCL, gefitinib, lapatinib ditosylate, pazopanib HCL, sorafenib tosylate, sunitinib malate, vandetanib, bortezomib, carfilzomib, dasatinib, everolimus, ibrutinib, idelalisib, imatinib mesylate, nilotinib HCL, ruxolitinib phosphate, trametinib dimethyl sulfoxide, vemurafenib, crizotinib, ponatinib HCL, regorafenib
03/08/2018
Incident Use of Rivaroxaban
Exploratory Analyses
rivaroxaban
03/07/2018
Selected Medications and Death, with Linkage of Mini-Sentinel Distributed Database with NDI+
Exploratory Analyses
dronedarone, norfloxacin, erythromycin, sulfamethoxazole/​trimethoprim, clarithromycin, telithromycin, paroxetine, fluoxetine, duloxetine, amiodarone, dofetilide, flecainide, propafenone, sotalol, azithromycin, amoxicillin, amoxicillin with clavulanate, ciprofloxacin, levofloxacin, clindamycin, cephalexin, penicillin V, gemifloxacin, moxifloxacin, ofloxacin, citalopram, escitalopram, fluvoxamine, sertraline, vilazodone, desvenlafaxine, venlafaxine, levomilnacipran, nefazodone, trazodone, vortioxetine, amitriptyline, amoxapine, doxepin, imipramine, nortriptyline, desipramine, protriptyline, clomipramine, trimipramine, mirtazapine, maprotiline
sudden cardiac death
03/06/2018
Drug Utilization Over Time for Three Drug Classes
Exploratory Analyses
tumor necrosis factor (TNF) alpha inhibitor, intravenous (IV) iron, granulocyte colony-stimulating factor (GC-SF)
03/05/2018
Combined Oral Contraceptives Containing Ethinyl Estradiol and Levonorgestrel and Venous Thromboembolism
Safety Analyses
combined oral contraceptive (COC)
venous thromboembolism (VTE)
03/04/2018
Venous Thromboembolism Following Continuous or Extended Cycle Contraceptive Use: A Propensity Score Matched Analysis
Safety Analyses
combined oral contraceptive (COC)
venous thromboembolism (VTE)
03/04/2018
Counts, Prevalence, and Incidence of Intravenous (IV) Iron Products
Exploratory Analyses
ferumoxytol, iron dextran complex, iron sucrose complex, sodium ferric gluconate complex
03/02/2018
Exposure to Intravenous (IV) Iron Procedures and Anaphylaxis and Epinephrine Events
Safety Analyses
intravenous (IV) iron
anaphylaxis
epinephrine event
03/02/2018
Rhabdomyolysis and/​or Creatine Kinase Laboratory Results Following New Use of Statins or Angiotensin-Converting Enzyme Inhibitors
Exploratory Analyses
statin, angiotensin-converting enzyme (ACE) inhibitor
creatine kinase laboratory result
rhabdomyolysis
03/01/2018
Use of Tyrosine Kinase Inhibitors (TKIs)
Exploratory Analyses
tyrosine kinase inhibitor, axitinib, sorafenib, sunitinib, pazopanib
02/28/2018
Length of Follow-up Time for New Users of Immunosuppressive Drugs
Exploratory Analyses
adalimumab, certolizumab, dalfampridine, dimethyl fumarate, etanercept, glatiramer acetate, golimumab, infliximab, interferon beta-1A, interferon beta-1B, natalizumab, teriflunomide, ustekinumab, alemtuzumab, fingolimod, mitoxantrone, pegylated interferon beta-1A
02/28/2018
Prevalent and Incident Dispensings of Ranolazine
Safety Analyses
ranolazine
02/26/2018
Boceprevir, Ledipasivir/​Sofosbuvir, Simeprevir Sodium, Sofosbuvir, and Telaprevir Use
Exploratory Analyses
boceprevir, telaprevir, simeprevir sodium, sofosbuvir, ledipasivir/​sofosbuvir
hepatitis C
02/05/2018
Concomitant Use of Opioid Analgesics and Cytochrome P450 (CYP) Inhibitors and Inducers
Safety Analyses
oxycodone, oxymorphone, CYP inhibitor, CYP inducer
02/01/2018
Metabolic Effects of Second Generation Antipsychotics in Youth, Subprojects 1, 2, and 3
Safety Analyses
second generation antipsychotic (SGA), olanzapine, risperidone, aripiprazole, quetiapine
metabolic syndrome
type 2 diabetes mellitus
weight gain
02/01/2018
Prevalent and Incident Use of SGLT2 Inhibitors
Exploratory Analyses
canagliflozin, dapagliflozin propanediol, empagliflozin, canagliflozin/​metformin HCl, dapagliflozin/​metformin HCl, empagliflozin/​linagliptin
02/01/2018
PROMPT: Rivaroxaban Surveillance
Safety Analyses
rivaroxaban, warfarin
gastrointestinal (GI) bleed
intracranial hemorrhage
ischemic stroke
01/31/2018
Antiepileptic Drug (AED) Injection Procedure Codes
Exploratory Analyses
anti-epileptic drug (AED)
01/31/2018
Counts of Commonly Used Angiostensin-Converting Enzyme (ACE) Inhibitors and Beta Blockers
Exploratory Analyses
angiotensin-converting enzyme (ACE) inhibitor, beta blocker
01/29/2018
Drug and Medical Enrollment Counts
Exploratory Analyses
01/29/2018
A Protocol for Assessment of Dabigatran and Selected Safety Outcomes
Safety Analyses
dabigatran, warfarin
intracranial hemorrhage
ischemic stroke
major extracranial hemorrhage
01/26/2018
Use of Tumor Necrosis Factor (TNF) Blocker Drugs
Exploratory Analyses
tumor necrosis factor (TNF) blocker
01/26/2018
Characterization of Pediatric Medical Conditions: Respiratory Syncytial Virus (RSV) Associated Illness
Exploratory Analyses
respiratory syncytial virus (RSV)
01/25/2018
Molecularly Targeted Anti-Cancer Therapies
Exploratory Analyses
bicalutamide, tamoxifen citrate, everolimus, axitinib, crizoatinib, dasatinib, erlotinib HCL, gefitinib, imatinib mesylate, lapatinib ditosylate, nilotinib HCL, pazopanib HCL, ruxolitinib phosphate, sorafenib tosylate, sunitinib malate, vandetanib, vemurafenib, vismodegib
01/24/2018
Stroke Diagnosis Codes
Exploratory Analyses
stroke
01/18/2018
Length of Enrollment in Pediatric Population
Exploratory Analyses
01/17/2018
Prevalent and Incident Use of Isotretinoin
Exploratory Analyses
isotretinoin
01/16/2018
Occurrence of Selected Generic Drugs 13
Exploratory Analyses
efalizumab, leflunomide, propylthiouracil, rosiglitazone maleate, lamotrigine, metoclopramide HCL, quinine, quinine sulfate, varenicline tartrate, sibutramine HCL m-hydrate, amlodipine besylate, ibandronate sodium, maraviroc, ramipril, tadalafil, nitrofurantoin, nitrofurantoin macrocrystal, nitrofurantoin monohyd/​m-crystal
01/11/2018
Clostridium Difficile Prevalence and Vancomycin, Fidaxomicin, and Tocilizumab Use
Exploratory Analyses
fidaxomicin, tocilizumab, vancomycin
clostridium difficile
01/08/2018
Use of Dronedarone HCL
Exploratory Analyses
dronedarone HCL
01/08/2018
Incident and Prevalent Dispensings of Mirabegron
Exploratory Analyses
mirabegron
01/01/2018
Use of Ospemifene, Boceprevir, and Telaprevir
Exploratory Analyses
boceprevir, ospemifene, telaprevir
12/29/2017
Prevalent and Incident Use of Testosterone Products
Exploratory Analyses
testosterone
12/21/2017
Top 100 Procedures and Diagnoses 30 Days Surrounding Incident Warfarin Use
Exploratory Analyses
warfarin
12/21/2017
Anti-Tumor Necrosis Factor (TNF) Utilization Among Pregnant Women
Exploratory Analyses
tumor necrosis factor (TNF) alpha inhibitor, adalimumab, infliximab, golimumab, etanercept, certolizumab
12/20/2017
Prevalent and Incident Use of Romiplostim
Exploratory Analyses
romiplostim
12/18/2017
Suicide Diagnoses
Exploratory Analyses
suicide
12/15/2017
Incident and Prevalent Use of Generic Drugs for Overactive Bladder
Exploratory Analyses
solifenacin succinate, darifenacin hydrobromide, fesoterodine fumarate, oxybutynin chloride, tolterodine tartrate, trospium chloride
12/11/2017
Use of Cancer Drugs
Exploratory Analyses
crizoatinib, ipilimumab, nivolumab, pembrolizumab, erlotinib HCL
12/08/2017
Antipsychotic Use and Dementia Diagnoses
Exploratory Analyses
antipsychotic
dementia
12/07/2017
Genetic Testing Procedures
Exploratory Analyses
12/05/2017
Atrial Fibrillation Prevalence
Exploratory Analyses
atrial fibrillation
atrial flutter
12/04/2017
Mycophenolate Dispensings and Procedures
Exploratory Analyses
mycophenolate mofetil, mycophenolate sodium, mycophenolate mofetil HCL
12/01/2017
Mycophenolate Dispensings and Procedures (by Quarter)
Exploratory Analyses
mycophenolate sodium, mycophenolate mofetil, mycophenolate mofetil HCL
12/01/2017
Niacin and Fenofibrate Use and Outcomes with Propensity Score Matching
Safety Analyses
extended-release (ER) niacin, fenofibrate
gastrointestinal (GI) bleed
intracranial hemorrhage
ischemic stroke
11/06/2017
Stroke Following Typical or Atypical Antipsychotic Use in Non-Elderly Patients: A Propensity Score Matched Analysis
Exploratory Analyses
antipsychotic
stroke
11/02/2017
Stroke Following Atypical Antipsychotic or Z-Hypnotic Use in Patients with Prior Use of Selective Serotonin Reuptake Inhibitors (SSRIs): A Propensity Score Matched Analysis
Exploratory Analyses
olanzapine, quetiapine, risperidone, aripiprazole, fluoxetine
stroke
11/02/2017
Antipsychotics and Stroke
Exploratory Analyses
olanzapine, quetiapine, risperidone, aripiprazole, typical antipsychotic, atypical antipsychotic, haloperidol, olanzapine/​fluoxetine, selective serotonin reuptake inhibitor (SSRI)
intracranial hemorrhage
ischemic stroke
11/01/2017
Sodium/​Glucose Cotransporter (SGLT2) Inhibitors- Type 1 and Type 2 Diabetes Cohort Identification
Exploratory Analyses
sodium-glucose cotransporter-2 (SGLT-2) inhibitor, sulfonylurea, dipeptidyl peptidase-4 (DPP-4) inhibitor
diabetes
type 1 diabetes mellitus
type 2 diabetes mellitus
10/30/2017
Niacin and Niacin Combination Products, Fenofibrates, and Omega-3 Products
Exploratory Analyses
niacin, niacin/​simvastatin, fenofibrate, niacin/​lovastatin, omega-3 product
10/12/2017
Alosetron Use
Exploratory Analyses
alosetron HCL
10/11/2017
Mirabegron Use
Exploratory Analyses
mirabegron
10/11/2017
Pegylated Products Use
Exploratory Analyses
certolizumab pegol, methoxy peg-epoetin beta, pegademase bovine, peginterferon beta-1a, pegloticase, pegvisomant
10/06/2017
Pegylated Products Follow-Up Request
Exploratory Analyses
10/06/2017
New Molecular Entities
Exploratory Analyses
alcaftadine, alglucosidase alfa, cabazitaxel, carglumic acid, ceftaroline fosamil acetate, collagenase clostridium histolyticum, dabigatran etexilate mesylate, dalfampridine, denosumab, eribulin mesylate, estradiol valerate/​dienogest, fingolimod HCL, incobotulinumtoxina, liraglutide, lurasidone HCL, pegloticase, polidocanol, tesamorelin acetate, tocilizumab, ulipristal acetate, velaglucerase alfa, boceprevir, clobazam, ezogabine, rivaroxaban, tenofovir disoproxil fumarate, tofacitinib citrate, abiraterone acetate, ziv-aflibercept, avanafil, asparaginase, azilsartan medoxomil, belatacept, belimumab, deferiprone, fidaxomicin, gabapentin enacarbil, gadobutrol, icatibant acetate, indacterol maleate, ioflupane i-123, ipilimumab, linagliptin, rilpivirine HCL, roflumilast, ruxolitinib phosphate, spinosad, telaprevir, ticagrelor, vandetanib, vemurafenib, vilazodone HCL, aclidinium bromide, apixaban, axitinib, bedaquiline fumarate, bosutinib, cabozantinib, carfilzomib, crofelemer, cobicistat, elvitegravir, enzalutamide, florbetapir f-18, glucarpidase, ingenol mebutate, ivacaftor, linaclotide, lomitapide mesylate, lorcaserin HCl, lucinactant, ocriplasmin, omacetaxine mepesuccinate, pasireotide diaspartate, teduglutide, teriflunomide, vismodegib, ado-trastuzumab emtansine, afatinib dimaleate, albiglutide, alogliptin benzoate, apremilast, belinostat, blinatumomab, canagliflozin, ceftolozane, tazobactam, ceritinib, dabrafenib mesylate, dalbavancin HCL, dapagliflozin propanediol, dimethyl fumarate, dolutegravir sodium, droxidopa, dulaglutide, efinaconazole, eliglustat tartrate, elosulfase alfa, empagliflozin, eslicarbazepine acetate, estrogen, bazedoxifene, flutemetamol f-18, fluconazole, vilanterol, gadoterate meglumine, ibrutinib, idelalisib, ledipasvir, luliconazole, macitentan, metreleptin, miltefosine, mipomersen sodium, naloxegol oxalate, netupitant, palonosetron HCL, nintedanib esylate, nivolumab, obinutuzumab, olaparib, olodaterol HCL, ombitasvir, paritaprevir, oritavancin diphosphate, ospemifene, peginterferon beta-1a, pembrolizumab, peramivir, pirfenidone, pomalidomide, radium-223 dichloride, ramucirumab, riociguat, siltuximab, simeprevir sodium, sofosbuvir, sulfur hexafluoride microsphere, suvorexant, tasimelteon, pitavastatin, tedizolid phosphate, trametinib dimethyl sulfoxide, umeclidinium, vedolizumab, vorapaxar sulfate, vortioxetine hydrobromide, alectinib HCL, alirocumab, aripiprazole, aripiprazole lauroxil, asfotase alfa, brexpiprazole, cangrelor tetrasodium, cariprazine HCL, ceftazidime/​avibactam, cholic acid, cobimetinib fumarate, daclatasvir dihydrochloride, daratumumab, deoxycholic acid, dinutuximab, edoxaban tosylate, elotuzumab, eluxadoline, elvitegravir/​cobicistat/​emtricitabine/​tenofovir, evolocumab, flibanserin, idarucizumab, insulin degludec, isavuconazonium sulfate, ivabradine HCL, ixazomib citrate, lenvatinib mesylate, lumacaftor/​ivacaftor, mepolizumab, necitumumab, osimertinib mesylate, palbociclib, panobinostat lactate, parathyroid hormone, patiromer calcium sorbitex, rolapitant HCL, sacubitril/​valsartan, sebelipase alfa, secukinumab, selexipag, sonidegib phosphate, sugammadex sodium, trabectedin, trifluridine/​tipiracil HCL, uridine
10/04/2017
Indications of Use Among Oral Antifungal Drug Users
Exploratory Analyses
ketoconazole, fluconazole, itraconazole, terbinafine, griseofulvin
09/01/2017
Actemra (Tocilizumab) Utilization Among Pregnant Women
Exploratory Analyses
Actemra, tocilizumab
juvenile rheumatoid arthritis
rheumatoid arthritis
07/18/2017
Anti-epileptic Drugs and Angioedema
Exploratory Analyses
levetiracetam, lamotrigine, phenytoin, lacosamide, oxcarbazepine
angioedema
07/17/2017
Multiple Births and Preterm Deliveries
Exploratory Analyses
preterm delivery
05/10/2017
Drug Use Following Genetic Testing Among Patients with Cancer
Exploratory Analyses
KRAS, BRAF, estimated glomerular filtration rate (eGFR), BCR-ABL, BRCA, cobimetinib fumarate, trametinib dimethyl sulfoxide, dabrafenib mesylate, vemurafenib, afatinib dimaleate, gefitinib, osimertinib mesylate, erlotinib HCL, bosutinib, imatinib mesylate, ponatinib HCL, dasatinib, nilotinib HCL, olaparib, cetuximab, panitumumab
cancer
05/10/2017
Influenza Antiviral Drug Use 2010-2015
Exploratory Analyses
oseltamivir, zanamivir
05/02/2017
Prevalent Dispensings of Ticagrelor (Brilinta) and Vortioxetine Hydrobromide (Brintellix)
Exploratory Analyses
vortioxetine hydrobromide, Brintellix, ticagrelor, Brilinta
04/23/2017
Attention Deficit Hyperactivity Disorder (ADHD) Medications and Heart Failure
Exploratory Analyses
amphetamine, methylphenidate, Strattera
heart failure
10/25/2016
PROMPT: Mirabegron Surveillance
Exploratory Analyses
mirabegron, oxybutynin
acute myocardial infarction (AMI)
stroke
09/21/2016
Dronedarone and Electrocardiograms
Exploratory Analyses
dronedarone
electrocardiogram
08/16/2016
Parenteral Iron and Anaphylactoid Reactions
Safety Analyses
parenteral iron (IV iron)
anaphylactoid reaction
07/22/2016
Dabigatran and Warfarin Use Among Members with Atrial Fibrillation and Other Pre-Existing Conditions
Exploratory Analyses
dabigatran, warfarin
07/21/2016
MRI and GBCA Procedures
Exploratory Analyses
07/21/2016
Hysterectomy Procedures Among Females
Exploratory Analyses
hysterectomy
morcellation
uterine fibroid
07/21/2016
Most Frequent Generic Dispensings Among Members Aged 65+
Exploratory Analyses
07/21/2016
Incident Testosterone Indication Diagnoses and Testosterone Use
Exploratory Analyses
testosterone
07/06/2016
Hypogonadism and Testosterone Use
Exploratory Analyses
testosterone
hypogonadism
07/06/2016
Incident Testosterone Use
Exploratory Analyses
testosterone
07/06/2016
Immunoglobulin Products and Hemolysis
Exploratory Analyses
immunoglobulin (Ig)
hemolysis
07/06/2016
Isotretinoin and Long-term Antibiotic Use and Multiple Sclerosis
Exploratory Analyses
isotretinoin, long-term antibiotic, doxycycline, minocycline, erythromycin, lamivudine, zidovudine, abacavir
multiple sclerosis
06/30/2016
Epidural Steroid Use
Exploratory Analyses
epidural steroid
06/30/2016
New Use of Statins and Rhabdomyolysis
Exploratory Analyses
statin, atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin
rhabdomyolysis
06/30/2016
Serum Creatinine Procedures and Labs
Exploratory Analyses
06/30/2016
Laparoscopic Hysterectomy With and Without Robotic Assistance and Adverse Outcomes
Exploratory Analyses
laparoscopic hysterectomy
intraoperative complication
medical complication
surgical site complication
06/21/2016
New Use of Dabigatran or Warfarin and Gastrointestinal Hemorrhage or Intracerebral Hemorrhage Events
Exploratory Analyses
dabigatran, warfarin
gastrointestinal hemorrhage
intracerebral hemorrhage (ICH)
06/21/2016
New Use of Anti-Epileptic Drugs and Agranulocytosis
Exploratory Analyses
anti-epileptic drug (AED), levetiracetam, lamotrigine, topiramate, carbamazepine
absolute neutrophil count (ANC)
agranulocytosis
06/21/2016
Omalizumab or Montelukast Use Among Individuals with Asthma and Acute Myocardial Infarction, Stroke, Intracranial Hemorrhage, or Pulmonary Embolism
Exploratory Analyses
omalizumab
acute myocardial infarction (AMI)
intracranial hemorrhage
stroke
06/21/2016
IVIg Product Use and Hemolysis Events
Exploratory Analyses
Gammagard, flebogamma, Gammaplex, Gamunex, Octagam, Privigen, intravenous immunoglobulin (IVIg)
06/03/2016
Incident Use of Testosterone Products Among All Members and Members with Pre-Existing Testosterone Use
Exploratory Analyses
Androgel, testosterone cypionate, Axiron, Fortesta, Testim, Striant, methyltestosterone, testosterone, testosterone suspension, testosterone enanthate, testosterone propionate, testosterone pellet, intramuscular testosterone, transdermal testosterone
06/03/2016
Concomitant Use of Niacin and Statins and Concomitant Use of Fenofibrates and Statins
Exploratory Analyses
statin, niacin, fenofibrate
06/03/2016
Anticoagulant Use Among Members with Atrial Fibrillation and Various Pre-Existing Exlusions
Exploratory Analyses
anticoagulant, dabigatran, warfarin
05/27/2016
Anticoagulant Use Among Members with Pre-Existing Atrial Fibrillation and Various Pre-Existing Exclusions
Exploratory Analyses
anticoagulant, dabigatran, warfarin
05/25/2016
Anticoagulants and Bleeding Events
Exploratory Analyses
dabigatran, warfarin, anticoagulant
bleeding event
05/20/2016
Antidepressant Use and Bleeding Events
Exploratory Analyses
antidepressant, selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), tricyclic
bleeding event
gastrointestinal hemorrhage
intracerebral hemorrhage (ICH)
05/20/2016
Dabigatran Uptake and Persistence
Exploratory Analyses
dabigatran
05/20/2016
Incident Antipsychotic Use
Exploratory Analyses
aripiprazole, olanzapine, quetiapine, risperidone, antipsychotic, asenapine, clozapine, iloperidone, lurasidone, paliperidone, ziprasidone
05/20/2016
Indications of Intravenous Immunoglobulin Use
Exploratory Analyses
intravenous immunoglobulin (IVIg)
05/20/2016
Anticoagulant Use Among Patients with Atrial Fibrillation
Exploratory Analyses
anticoagulant, oral formulation of apixaban, dabigatran, rivaroxaban, warfarin
01/31/2016
Drug Use Among Pregnant Women with Live Births
Exploratory Analyses
methotrexate, valproic acid, ribavirin, simvastatin, lisinopril, mycophenolate mofetil, paroxetine, sodium valproate, selective serotonin reuptake inhibitor (SSRI), statin, anticonvulsant, angiotensin-converting enzyme (ACE) inhibitor, warfarin, dabigatran
01/30/2016
Anti-Diabetes Drugs and Acute Myocardial Infarction, Hospitalized Heart Failure
Safety Analyses
anti-diabetic agent (ADA), hypoglycemic drug, dipeptidyl peptidase-4 (DPP-4) inhibitor, sulfonylurea, thiazolidinedione, saxagliptin, sitagliptin, pioglitazone, glimepiride, glipizide, glyburide, long-acting insulin
acute myocardial infarction (AMI)
heart failure
01/26/2016
Select Bisphosphonates and Select Outcomes of Interest
Exploratory Analyses
biphosphonate
esophageal cancer
fracture
hip fracture
non-vertebral fracture
osteonecrosis of the jaw
03/14/2015
Anaphylaxis Events Following Incident Vaccine Exposure Among Members with a Pre-Existing Condition of Milk Allergy
Exploratory Analyses
diphtheria, tetanus, acellular pertussis (DTaP) vaccine, diphtheria, tetanus, acellular pertussis (DTaP)-hepatitis B (Hep B)-inactivated polio vaccine (IPV), diphtheria, tetanus, acellular pertussis (DTaP)-haemophilus influenzae type B (HIB) vaccine, diphtheria, tetanus, acellular pertussis (DTaP)-haemophilus influenzae type B (HIB)-inactivated polio vaccine (IPV), diphtheria, tetanus, acellular pertussis (DTaP)-inactivated polio vaccine (IPV), tetanus, diphtheria, pertussis (Tdap) vaccine
anaphylactic shock
03/03/2015
Omalizumab and Montelukast Use
Exploratory Analyses
omalizumab, montelukast
02/25/2015
Gastrointestinal Disorders
Exploratory Analyses
entercolitis
gastrointestinal disorder
ileocolitis
procitis
proctosigmoiditis
pseudopolyposis
regional enteritis
ulcerative colitis
02/25/2015
Injection Omalizumab Procedure Codes
Exploratory Analyses
omalizumab
02/25/2015
Omalizumab Use
Exploratory Analyses
omalizumab
02/25/2015
Prevalent and Incident Use of Pramipexole
Exploratory Analyses
pramipexole
02/25/2015
Hypoglycemic Events Following Use of Anti-Diabetic Agents (ADAs)
Exploratory Analyses
anti-diabetic agent (ADA), chlorpropamide, glimepiride, glipizide, glyburide, metformin, tolazamide, pioglitazone, rosiglitazone maleate, insulin, glipizide/​metformin, glyburide/​metformin, pioglitazone/​metformin, rosiglitazone/​metformin
hypoglycemia
02/25/2015
Progressive Multifocal Leukoencephalapathy
Exploratory Analyses
progressive multifocal leukoencephalopathy (PML)
02/24/2015
Methotrexate and Tofacitinib Use
Exploratory Analyses
methotrexate, methotrexate sodium, methotrexate sodium, preservative free, tofacitinib citrate
11/24/2014
Incident and Prevalent Use of Alvimopan, Naltrexone, and Methylnaltrexone
Exploratory Analyses
alvimopan, methylnaltrexone bromide, morphine sulfate/​naltrexone, naltrexone, naltrexone HCL, naltrexone microsphere
11/23/2014
Procedure Codes Related to Memory Gel Breast Implants
Exploratory Analyses
breast implant
11/10/2014
Opioid Medication Use
Exploratory Analyses
Suboxone, Subutex, Buprenex, Butrans, generic oral buprenorphine, generic injectable buprenorphine, generic powder buprenorphine, opioid
11/09/2014
Buprenorphine Product Use
Exploratory Analyses
buprenorphine
11/09/2014
CPAX Aneurysm Procedure Codes
Exploratory Analyses
CPAX aneurysm
emboli detection
intravenous microbubble injection
surgery of intracranial aneurysm
transcranial doppler study
10/21/2014
Lap-band Diagnosis Codes
Exploratory Analyses
gastric lap band
bariatric surgery
gastric band procedure
10/20/2014
Ascension Metacarpophalangeal Diagnoses
Exploratory Analyses
Ascension metacarpophalangeal (MCP)
arthritis
diffuse disease of connective tissue
osteoarthritis
sprain and strain of metacarpophalangeal of hand
traumatic arthropathy
10/16/2014
Ascension Metacarpophalangeal Procedures
Exploratory Analyses
arthroplasty metacarpophalangeal interphalangeal joint
arthrotomy for removal of prosthesis
division of joint
10/16/2014
CPAX Aneurysm Diagnoses
Exploratory Analyses
CPAX aneurysm
aneurysm
arthropod-borne hemorrhagic fever
cerebral aneurysm nonruptured
intracerebral hemorrhage (ICH)
mosquito-borne viral encephalitis
subarcahnoid hemorrhage
10/16/2014
Activa Tremor Control Procedures
Exploratory Analyses
Activa Tremor Control
10/16/2014
Activa Tremor Control Diagnoses
Exploratory Analyses
neuropacemaker
Activa Tremor Control
essential tremor
other specified forms of tremor
paralysis agitans
10/15/2014
Dialysis HCPCS Procedure Codes
Exploratory Analyses
dialysis
end-stage renal disease (ESRD)
kidney failure
10/14/2014
Dialysis ICD9 Diagnosis Codes
Exploratory Analyses
dialysis
end-stage renal disease (ESRD)
kidney failure
10/13/2014
Dialysis ICD9 Procedure Codes
Exploratory Analyses
dialysis
end-stage renal disease (ESRD)
kidney failure
10/13/2014
Anti-Infective Agents Use 2
Exploratory Analyses
anti-infective agent
09/23/2014
Cardiovascular Therapy Agent Use 2
Exploratory Analyses
cardiovascular therapy agent, acebutolol HCL
09/23/2014
Gastrointestinal Therapy Agents Use 2
Exploratory Analyses
gastrointestinal therapy agent
09/23/2014
Antiepileptic Drugs (AEDs) and Kidney Stones 2
Exploratory Analyses
anti-epileptic drug (AED), topiramate, gabapentin, zonisamide, lamotrigine, levetiracetam, carbamazepine, oxcarbazepine, phenytoin, valproic acid
kidney stone
09/23/2014
Infectious Disease Diagnoses
Exploratory Analyses
Chagas disease
anthrax
ascariasis
hepatitis
hepatitis C
hookworm
influenza
leishmaniasis
malaria
methicillin-resistant Staphylococcus aureus (MRSA)
plague
schistosomiasis
trichuriasis
tuberculosis (TB)
tularemia
09/23/2014
Occurrence of Selected Generic Drugs 12
Exploratory Analyses
09/22/2014
Analgesic Use 3
Exploratory Analyses
analgesic
08/12/2014
Diabetes Diagnoses and Occurrence of Laboratory Results
Exploratory Analyses
06/12/2014
Anti-D, Dexamethasone, Prednisone, Romiplostim and Hemolysis
Exploratory Analyses
anti-D, dexamethasone, prednisone, romiplostim
hemolysis
06/10/2014
Immune Globulin Use
Exploratory Analyses
immune globulin, gamma caprylate (IgG), immune globulin, gamma (IgG)/maltose, immune globulin, gamma (IgG)
06/05/2014
Hemorrhagic Disorder Diagnoses
Exploratory Analyses
acquired hemophilia
hemorrhagic disorder
06/04/2014
Injection Gammagard Use
Exploratory Analyses
Gammagard
06/04/2014
Occurrence of Kidney Stones
Exploratory Analyses
anti-diabetic agent (ADA)
kidney stone
02/25/2014
Hemodialysis Procedures
Exploratory Analyses
hemodialysis
01/12/2014
Enoxaparin Sodium Use
Exploratory Analyses
enoxaparin sodium
01/12/2014
Injection Enoxaparin Sodium Use
Exploratory Analyses
enoxaparin sodium
01/12/2014
Acute Kidney Failure Diagnoses
Exploratory Analyses
acute kidney failure
01/11/2014
Occurrence of Selected Dental HCPCS Codes
Exploratory Analyses
01/11/2014
Nursing Home Facility HCPCS Codes
Exploratory Analyses
01/10/2014
Prevalent and Incident Use of Acetazolamide
Exploratory Analyses
acetazolamide
01/09/2014
Long Acting Beta2-Agonists (LABA) Policies and Drug Utilization Patterns
Exploratory Analyses
long-acting beta2 agonist (LABA)
change in drug utilization patterns
01/09/2014
Anti-Seizure Medication Use
Exploratory Analyses
topiramate, phentermine HCl, phentermine resin, carbamazepine, felbamate, tiagabine HCL, levetiracetam, lamotrigine, pregabalin, gabapentin, phenytoin, phenytoin sodium, phenytoin sodium extended, oxcarbazepine, valproic acid, zonisamide, ethosuxamide
01/08/2014
Occurrence of Selected Generic Drugs 11
Exploratory Analyses
eltrombopag olamine, vigabatrin, telaprevir, rivaroxaban, febuxostat, benzyl alcohol, pitavastatin calcium, boceprevir, Pradaxa, dabigatran etexilate mesylate
01/08/2014
Multiple Sclerosis Medication Use
Exploratory Analyses
fingolimod HCL, glatiramer acetate, mitoxantrone HCL, interferon beta-1A, interferon beta-1A/​albumin, natalizumab, interferon beta-1B
01/08/2014
Multiple Sclerosis Medication Injections
Exploratory Analyses
injection natalizumab, injection glatiramer acetate, injection interferon beta-1B, injection mitoxantrone HCL, injection interferon beta-1A, injection interferon beta-1A
01/08/2014
Prevalent and Incident Use of Quinine Sulfate
Exploratory Analyses
quinine sulfate
01/08/2014
Quinine Sulfate, Diltiazem and Selected Thrombotic Events
Exploratory Analyses
quinine sulfate, diltiazem
hemolytic-uremic syndrome
immune thrombocytopenic purpura
other secondary thrombocytopenia
thrombotic microangiopathy
unspecified thrombocytopenia
01/08/2014
Antiepileptic Drugs (AEDs) and Kidney Stones
Exploratory Analyses
topiramate, carbamazepine, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, phenytoin, zonisamide, anti-epileptic drug (AED)
kidney stone
01/07/2014
Chronic Kidney Disease Diagnoses
Exploratory Analyses
chronic kidney disease (CKD)
12/29/2013
Nursing Home HCPCS Codes
Exploratory Analyses
12/29/2013
Oral Antifungal Use
Exploratory Analyses
fluconazole, voriconazole, itraconazole, ketoconazole, posaconazole, terbinafine
11/20/2013
Occurrence of Selected Generic Drugs 10
Exploratory Analyses
lapatinib, ticlopidine, telithromycin, allopurinol, diclofenac, isoniazid
11/20/2013
Antiepileptic Drug Use
Exploratory Analyses
acetazolamide, carbamazepine, clobazam, clonazepam, diazepam, ethosuxamide, ezogabine, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, lorazepam, oxcarbazepine, phenobarbital, phenytoin, pregabalin, primidone, rufinamide, tiagabine, topiramate, valproic acid, vigabatrin, zonisamide
11/20/2013
Propylthiouracil and Methimazole Use 2
Exploratory Analyses
propylthiouracil, methimazole
10/07/2013
Unspecified Anterior Pituitary Hyperfunction and Hypertrophy of the Breast Diagnoses
Exploratory Analyses
anterior pituitary hyperfunction
hypertrophy
10/07/2013
Occurrence of Selected Generic Drugs 9
Exploratory Analyses
warfarin sodium, valproic acid, ribavirin, ribavirin/​interferon alfa-2B, paroxetine HCL, paroxetine mesylate, mycophenolate mofetil, mycophenolate sodium, methotrexate, methotrexate sodium, ezetimibe/​simvastatin, niacin/​simvastatin, simvastatin, lisinopril, lisinopril/​dietary sup. Cmb10, lisinopril/​hydrochlorothiazide
10/07/2013
HIV and HBV Infection Diagnoses
Exploratory Analyses
hepatitis B virus (HBV)
human immunodeficiency virus (HIV)
10/07/2013
Bupropion HCL Sustained Release HCPCS Codes
Exploratory Analyses
bupropion HCL sustained release tablet
10/07/2013
Anti-Infective Agents Use
Exploratory Analyses
acyclovir, acyclovir sodium, atovaquone, doxycycline calcium, doxycline hyclate, nitazoxanide, norfloxacin, telithromycin, tenofovir disoproxil fumarate
09/14/2013
Cardiovascular Therapy Agents Use
Exploratory Analyses
acebutolol HCL, aliskiren hemifumarate, amlodipine besylate, ambrisentan, atenolol, betaxolol HCL, bosentan, captopril, carvedilol, conivaptan HCL, diltiazem HCL, eprosartan mesylate, indapamide, labetalol HCL, lisinopril, metoprolol succinate, metoprolol tartrate, metoprolol/​hydrochlorothiazide, nadolol, nimodipine, perindopril erbumine, propafenone HCL, trandolapril, triamterene
09/14/2013
Analgesic Use 2
Exploratory Analyses
acetaminophen with codeine, codeine sulfate, codeine phosphate, aspirin/​codeine phosphate, fentanyl citrate, methadone HCL, morphine sulfate, oxycodone HCL, oxymorphone HCL, sulindac, tramadol HCL
09/14/2013
Gastrointestinal Therapy Agents Use
Exploratory Analyses
aprepitant, fosaprepitant dimeglumine, cimetidine, dexlansoprazole, dicyclomine HCL, lubiprostone, mesalamine, nizatidine, sucralfate
09/13/2013
Occurrence of Selected Generic Drugs 7
Exploratory Analyses
solifenacin succinate, cyclosporine modified, cyclosporine, albuterol, alvimopan, chlorambucil, tretinoin, vorinostat, lindane, calcium acetate, phytonadione, albuterol sulfate, levalbuterol tartrate, levalbuterol HCL
07/17/2013
Occurrence of Selected Generic Drugs 8
Exploratory Analyses
ambrisentan, bosentan, isotretinoin, lenalidomide, thalidomide, buprenorphine HCL, rosiglitazone/​glimepiride, rosiglitazone/​metformin HCL, alvimopan, varenicline tartrate, propoxyphene HCL, alosetron HCL, sibutramine HCL, metoclopramide HCL, nilotinib HCL, bupropion HCL, sacrosidase, propoxyphene HCL/​acetaminophen, propoxyphene HCL/​ASA/​caffeine, ribavirin/​interferon alfa-2B, naloxone HCL
07/17/2013
Parkinson’s Disease Medication Use
Exploratory Analyses
carbidopa, entacapone, combination product of carbidopa, levodopa and entacapone (Stalevo), levodopa
06/07/2013
Oxicam NSAIDs, Modafinil/​Armodafinil, Sulfamothoxazole and Severe Cutaneous Adverse Reaction (SCAR) Events
Exploratory Analyses
oxicam, modafinil/​armodafinil, sulfamothoxazole, modafinil
severe cutaneous adverse reaction (SCAR)
06/07/2013
Angiotensin Receptor Blockers (ARBs), Hydrochlorothiazide, Atenolol, Amlodipine Use and Celiac Disease
Exploratory Analyses
angiotensin II receptor blocker (ARB), candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan, hydrochlorothiazide (HCTZ), atenolol, amlodipine
celiac disease
06/07/2013
Occurrence of Selected Pediatric Drugs 1
Exploratory Analyses
acetaminophen with codeine, acyclovir, albuterol, nizatidine, sucralfate
06/07/2013
Vascular Endothelial Growth Factor (VEGF) Inhibitor Prevalent and Incident Use
Exploratory Analyses
vascular endothelial growth factor (VEGF) inhibitor, thalidomide, bevacizumab, sorafenib, sunitinib
05/09/2013
Dabigatran, Rivaroxaban, and Warfarin Use
Exploratory Analyses
dabigatran, rivaroxaban, warfarin
05/03/2013
Dabigatran, Warfarin and GI Bleed, Intracerebral Hemorrhage
Exploratory Analyses
dabigatran, warfarin
gastrointestinal hemorrhage
intracerebral hemorrhage (ICH)
serious bleeding
05/03/2013
Warfarin and GI Bleed, Intracerebral Hemorrhage
Exploratory Analyses
warfarin
gastrointestinal hemorrhage
intracerebral hemorrhage (ICH)
serious bleeding
05/03/2013
Dabigatran (Pradaxa), Warfarin and GI Bleed, Intracerebral Hemorrhage
Safety Analyses
anticoagulant, blood thinner, dabigatran, warfarin, Coumadin, Pradaxa
gastrointestinal hemorrhage
intracerebral hemorrhage (ICH)
serious bleeding
02/11/2013
Selgiline Use
Exploratory Analyses
selgiline
01/10/2013
Lindane Use Modular Program
Exploratory Analyses
lindane
01/10/2013
Natalizumab, Efalizumab, and Progressive Multifocal Leukoencephalopathy (PML)
Exploratory Analyses
natalizumab, efalizumab
progressive multifocal leukoencephalopathy (PML)
01/10/2013
Duloxetine, Pregabalin, and Milnacipran Use 2
Exploratory Analyses
duloxetine, pregabalin, milnacipran
01/09/2013
Clopidogrel and Prasugrel Use
Exploratory Analyses
clopidogrel, prasugrel
01/09/2013
Bupropion and Naltrexone Use 2
Exploratory Analyses
bupropion, naltrexone
01/09/2013
Bupropion and Naltrexone Use 1
Exploratory Analyses
bupropion, naltrexone
01/09/2013
Duloxetine, Pregabalin, and Milnacipran Use 1
Exploratory Analyses
duloxetine, pregabalin, milnacipran
01/09/2013
Amphotericin Use
Exploratory Analyses
amphotericin B, amphotericin B lipid complex, amphotericin B cholesteryl sulfate, amphotericin B liposome
01/07/2013
Isoniazid Use
Exploratory Analyses
isoniazid, rifampin/​isoniazid, rifampin/​isoniazid/​pyrazinamid
01/07/2013
Boceprevir and Telaprevir Use
Exploratory Analyses
telaprevir, boceprevir
01/07/2013
Injection Amphotericin Procedures
Exploratory Analyses
injection amphotericin B, injection amphotericin B lipid form, injection amphotericin B lipid complex, injection amphotericin B cholesteryl, injection amphotericin B liposome
01/07/2013
Hip Implant Procedures and Diagnoses 2
Exploratory Analyses
acetabular component
acquired hemophilia
femoral component
mechanical complication of internal orthopedic device implant and graft
partial hip replacement
total hip replacement
01/07/2013
Occurrence of Selected Generic Drugs 6
Exploratory Analyses
zidovudine, stavudine, didanosine, lamivudine, emtricitabine, abacavir sulfate, entecavir, tenofovir disoproxil fumarate, emtricitabine/​tenofovir, efavirenz/​emtricitab/​tenofovir, didanosine/​calcium carb/​mag, didanosine/​sodium citrate
01/07/2013
Nucleoside Reverse Transcriptase Inhibitor Procedures
Exploratory Analyses
injection zidovudine, zidovudine oral, didanosine
01/07/2013
Occurrence of Selected Generic Drugs 3
Exploratory Analyses
ambrisentan, bosentan, buprenorphine HCL, fentanyl, hydromorphone HCL, isotretinoin, lenalidomide, methadone HCL, morphine sulfate, oxycodone HCL, rosiglitazone maleate, rosiglitazone/​glimepiride, rosiglitazone/​metformin HCL, thalidomide, alosetron HCL, naloxone HCL
12/13/2012
Golimumab, Ustekinumab, and Dronedarone Hydrochloride Use (by Year)
Exploratory Analyses
golimumab, ustekinumab, dronedarone HCL
12/13/2012
Injection Ustekinumab and Injection Denosumab Procedures
Exploratory Analyses
injection ustekinumab
12/13/2012
Injection Natalizumab Procedures
Exploratory Analyses
injection natalizumab
12/13/2012
Occurrence of Selected Generic Drugs 4
Exploratory Analyses
modafinil, meloxicam, piroxicam, sulfamethoxazole, sulfamethoxazole/​trimethoprim
12/13/2012
Golimumab, Ustekinumab, and Dronedarone Hydrochloride Use (by Quarter)
Exploratory Analyses
golimumab, ustekinumab, dronedarone HCL
12/13/2012
Occurrence of Selected Generic Drugs 5
Exploratory Analyses
ambrisentan, bosentan, buprenorphine HCL, eltrombopag olamine, fentanyl, hydromorphone HCL, isotretinoin, lenalidomide, mifepristone, oxycodone HCL, romiplostim, rosiglitazone maleate, rosiglitazone/​glimepiride, rosiglitazone/​metformin HCL, thalidomide, vigabatrin, alosetron HCL
12/13/2012
Natalizumab and Efalizumab Use
Exploratory Analyses
natalizumab, efalizumab
12/13/2012
Drugs that Act on the Renin-Angiotensin-Aldosterone System (Angiotensin Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, Aliskiren) and Angioedema
Safety Analyses
angiotensin II receptor blocker (ARB), aliskiren, angiotensin-converting enzyme (ACE) inhibitor
angioedema
10/19/2012
Occurrence of Selected Generic Drugs 1
Exploratory Analyses
azathioprine, azathioprine sodium, benzonatate, cabergoline, everolimus, lopinavir/​ritonavir, mercaptopurine, ralegravir potassium, ribavirin, ribavirin A-2B, tolvaptan, voriconazole, tenofovir disoproxil fumarate
08/30/2012
Occurrence of Selected HCPCS Codes 1
Exploratory Analyses
combination peginterferon and ribavirin, cabergoline oral, mercaptopurine oral, negative pressure wound therapy (NPWT)
08/30/2012
Infliximab Use
Exploratory Analyses
infliximab
08/02/2012
Injection Infliximab Procedures
Exploratory Analyses
injection infliximab
08/02/2012
Analgesics Use
Exploratory Analyses
analgesic
08/02/2012
Dalfampridine Use
Exploratory Analyses
dalfampridine
08/02/2012
Propylthiouracil and Methimazole Use
Exploratory Analyses
propylthiouracil, methimazole
08/02/2012
Occurrence of Selected Generic Drugs 2
Exploratory Analyses
ambrisentan, bosentan, dronedarone, lisinopril, acitretin/​emollient combo. 26, isotretinoin, methimazole, methotrexate, methotrexate sodium, clarithromycin, fluconazole, telavancin, busulfan, chlorambucil, cyclophosphamide, lenalidomide, thalidomide, trastuzumab, topiramate, valproic acid, lithium carbonate, lithium citrate, finasteride, lisinopril/​hydrochlorothiazide, warfarin, acitretin
08/02/2012
Occurrence of Selected HCPCS Codes 2
Exploratory Analyses
busulfan, cyclophosphamide, methotrexate, trastuzumab, finasteride, chlorambucil
08/02/2012
Lindane Use Summary Table
Exploratory Analyses
lindane
06/22/2012
Regional Enteritis and Ulcerative Enterocolitis Diagnoses
Exploratory Analyses
Crohn's disease
regional enteritis
ulcerative enterocolitis
06/22/2012
Arthritis Diagnoses
Exploratory Analyses
Felty's syndrome
arthritis
inflammatory polyarthropathy
juvenile chronic polyarthritis
rheumatoid arthritis
06/22/2012
Clozapine Use
Exploratory Analyses
clozapine
06/19/2012
Use of Vascular Endothelial Growth Factor (VEGF) Inhibitors
Exploratory Analyses
vascular endothelial growth factor (VEGF) inhibitor, bevacizumab, sorafenib tosylate, sunitinib malate, thalidomide
06/19/2012
Bone Resorption Inhibitor Use (by Drug Class)
Exploratory Analyses
bone resorption inhibitor
06/19/2012
VEGF and Bone Resorption Inhibitor Procedures
Exploratory Analyses
bone resorption inhibitor procedure
vascular endothelial growth factor (VEGF)
06/19/2012
Negative Pressure Wound Therapy (NPWT) Procedures
Exploratory Analyses
negative pressure wound therapy (NPWT)
06/08/2012
Milk Allergy Diagnoses
Exploratory Analyses
milk allergy
05/11/2012
Hip Implant Procedures and Diagnoses
Exploratory Analyses
arthroplasty
hemiarthroplasty
hip implant
hip replacement
05/11/2012
Progressive Multifocal Leukoencephalopathy Diagnoses
Exploratory Analyses
progressive multifocal leukoencephalopathy (PML)
04/26/2012
Hyperlipidemia Diagnoses
Exploratory Analyses
hypercholesterolemia
hyperchylomicronemia
hyperglyceridemia
hyperlipidemia
04/26/2012
Heart/​Lung Resuscitation (CPR), Injection Diphenhydramine Hydrochloride (HCL), Injection Adrenaline Epinephrine Procedures
Exploratory Analyses
injection adrenaline epinephrine, injection diphenhydramine hydrochloride (HCL)
cardiopulmonary resuscitation (CPR)
04/26/2012
Unspecified Allergic Reaction Diagnoses
Exploratory Analyses
unspecified allergic reaction
04/26/2012
Cardiopulmonary Resuscitation (CPR) Not Otherwise Specified Procedures
Exploratory Analyses
cardiopulmonary resuscitation (CPR)
04/26/2012
Asthma Diagnoses
Exploratory Analyses
asthma
04/26/2012
Acute Myocardial Infarction Diagnoses
Exploratory Analyses
acute myocardial infarction (AMI)
04/25/2012
Aseptic Necrosis of Bone Jaw Diagnoses
Exploratory Analyses
aseptic necrosis of bone jaw
04/09/2012
Serious Cutaneous Adverse Reaction (SCAR) Diagnoses
Exploratory Analyses
severe cutaneous adverse reaction (SCAR)
04/09/2012
Angiotensin II Receptor Blockers and Celiac Disease
Exploratory Analyses
angiotensin II receptor blocker (ARB), candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan
celiac disease
01/16/2012
Smoking Cessation Drugs and Cardiovascular Outcomes
Safety Analyses
varenicline, bupropion
acute coronary occlusion without myocardial infarction
acute myocardial infarction (AMI)
cardiovascular outcome
intermediate coronary syndrome
unstable angina
01/15/2012
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