Stroke Following Atypical Antipsychotic or Z-Hypnotic Use in Patients with Prior Use of Selective Serotonin Reuptake Inhibitors (SSRIs): A Propensity Score Matched Analysis

    Basic Details
    Date Posted
    Wednesday, November 1, 2017
    Status
    Complete
    Medical Product
    aripiprazole
    fluoxetine
    olanzapine
    quetiapine
    risperidone
    Health Outcome(s)
    stroke
    Description

    This request investigated the association between selective serotonin reuptake inhibitors (SSRIs) users who initiate atypical antipsychotic use and the occurrence of stroke. Data from January 1, 2001 to September 30, 2015 from 10 Data Partners contributing to the Sentinel Distributed Database were included in this report. This request was distributed to Data Partners on April 14, 2017.

    • Report 1: Association between selective serotonin reuptake inhibitors (SSRIs) users who initiate the atypical antipsychotic olanzapine and the occurrence of stroke
    • Report 2: Association between selective serotonin reuptake inhibitors (SSRIs) users who initiate the atypical antipsychotic quetiapine and the occurrence of stroke
    • Report 3: Association between selective serotonin reuptake inhibitors (SSRIs) users who initiate the atypical antipsychotic risperidone and the occurrence of stroke
    • Report 4: Association between selective serotonin reuptake inhibitors (SSRIs) users who initiate the atypical antipsychotic aripiprazole and the occurrence of stroke
    • Report 5: Association between selective serotonin reuptake inhibitors (SSRIs) users who initiate any atypical antipsychotic and the occurrence of stroke
    • Report 6: Association between fluoxetine (a specific selective serotonin reuptake inhibitor (SSRI) users who initiate the atypical antipsychotic olanzapine and the occurrence of stroke.

    The analytic package associated with these reports can be found externally in Sentinel's Git Repository located here. The Git Repository serves as Sentinel's version control tracking system for analytic packages and technical documentation.