Use of Time-Dependent Propensity Scores to Adjust Hazard Ratio Estimates in Cohort Studies with Differential Depletion of Susceptibles

Project Title Use of Time-Dependent Propensity Scores to Adjust Hazard Ratio Estimates in Cohort Studies with Differential Depletion of Susceptibles
Description

Estimating hazard ratios (HR) presents challenges for time-to-event analyses of cohorts with differential depletion of susceptibles. When the treatment effect is not null, cohorts that were balanced at baseline tend to become unbalanced on baseline characteristics over time as 'susceptible' individuals drop out of the population at risk differentially across treatment groups due to having outcome events. Here, we present results from a series of simulations to help analysts gain insight on these issues.

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Published Date
Thursday, September 26, 2019
Category
Publications and Presentations