Disease Risk Score Exploratory Methods

Project Title Disease Risk Score Exploratory Methods
Date Posted
Tuesday, June 26, 2018
Status
Complete
Description

The objective of this workgroup was to design and implement hybrid empirical/simulated experiments to compare the performance of methods for (1) disease risk score (DRS) development; and (2) incorporating DRSs for multiple outcomes into the analysis to improve inference. The workgroup evaluated different approaches for developing DRSs and used a novel ‘dry run’ analysis approach to compare multiple analytic methods. Understanding the optimal approaches to DRS development and application in the distributed data and multiple outcome setting is critical for moving forward with DRS analyses in Sentinel.

Workgroup Leader(s)

Rishi J. Desai PhD, MS; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

Workgroup Members

Justin Bohn SD, SM; Yinzhu Jin MS, MPH; Joshua J. Gagne PharmD, ScD; Shirley V. Wang PhD; Richie Wyss PhD; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

Austin Cosgrove BS; Adee Kennedy MPH, MS; Sengwee Toh ScD; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

Sara Karami PhD, MPH; Clara Y. Kim PhD; Jessica Kim PhD; Aaron Niman MPH; Rita Ouellet-Hellstrom PhD; Jacqueline M. Puigbo PhD, MS; Center for Drug Evaluation and Research, FDA, Silver Spring, MD

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