Mini-Sentinel: Sequential Testing Methods

    Basic Details
    Date Posted
    Thursday, August 11, 2011
    Status
    Complete
    Description

    Methods project to develop and evaluate a method to incorporate regression adjustment to control for confounding in a group sequential design framework, including a simulation study comparing the new approach to existing approaches.

    Workgroup Leader(s)

    Andrea J. Cook, PhD; Biostatistics Unit, Group Health Research Institute, Seattle WA

    Workgroup Member(s)

    Ram C. Tiwari, PhD; Office of Biostatistics, Center for Drug Evaluation and Research, FDA, Silver Spring, MD

    Robert D. Wellman, MS; Biostatistics Unit, Group Health Research Institute, Seattle, WA

    Susan R. Heckbert, MD, PhD; Departments of Epidemiology and Pharmacy, University of Washington, Seattle, WA and Group Health Research Institute, Seattle, WA

    Lingling Li, PhD; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

    Patrick J. Heagerty, PhD; Department of Biostatistics, University of Washington, Seattle, WA

    Tracey L. Marsh, MS; Group Health Research Institute, Seattle, WA

    Jennifer C. Nelson, PhD; Biostatistics Unit, Group Health Research Institute, Seattle, WA and Department of Biostatistics, University of Washington, Seattle, WA