Comparative Risk for Angioedema Associated with the Use of Drugs that Target the Renin-Angiotensin-Aldosterone System

Project Title Comparative Risk for Angioedema Associated with the Use of Drugs that Target the Renin-Angiotensin-Aldosterone System
Date
Monday, November 12, 2012
Location

Archives of Internal Medicine, Volume 172, Issue 20, November 2012, Pages 1582-1589, DOI: 10.1001/2013

Description

This article describes a Mini-Sentinel protocol-based one-time assessment of the risk of angioedema associated with new use of drugs that act on the renin-angiotensin-aldosterone system (RAAS), including angiotensin converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), and aliskiren.

Medical Product
aliskiren
angiotensin II receptor blocker (ARB)
angiotensin-converting enzyme (ACE) inhibitor
Health Outcome
angioedema
Population / Cohort
All individuals 18 years of age or older
Time Period
2001 - 2010
Corresponding Author

S. Toh, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, 401 Park Drive, Suite 401 East, Boston, MA 02215, USA. Email: darren_toh@harvardpilgrim.org

Authors

Sengwee Toh ScD; Marsha E. Reichman PhD; Monika Houstoun PharmD; Mary Ross Southworth PharmD; Xiao Ding PhD; Adrian F. Hernandez MD; Mark Levenson PhD; Lingling Li PhD; Carolyn McCloskey MD, MPH; Azadeh Shoaibi MS, MHS; Eileen Wu PharmD; Gwen Zornberg MD, MS, ScD; Sean Hennessy PharmD, PhD

Data Sources
Mini-Sentinel Distributed Database (MSDD)
Related Assessments
Drugs that Act on the Renin-Angiotensin-Aldosterone System (Angiotensin Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, Aliskiren) & Angioedema
Publication Type
Publication
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