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Effectiveness and Safety of Cannabis on Anxiety Treatment Outcomes: A Systematic Review

Basic Details
Date
Type
Publication
Description

We assessed controlled non-interventional studies and randomized clinical trials (RCTs) evaluating THC-containing cannabis’ safety and effectiveness for anxiety.

We searched PubMed, Embase, APA PsychInfo, and Cochrane databases in February 2023 for clinical studies that reported patient-level controlled quantitative assessments of anxiety outcomes following cannabis treatment. Exclusion criteria included: publication before 2000, in non-English language, assessment of topical treatment or containing <0.3% tetrahydrocannabinol, and FDA-approved products. We assessed risk of bias via RoB2/ROBINS-I, and rated evidence quality using the GRADE approach. PROSPERO:CRD42023411999

Materials

J Affect Disord. 2026 Jun 01. doi.org/10.1016/j.jadr.2026.101095

Related Assessment(s)
Sentinel Methods Project: Medical Literature and Data on Cannabis Use
Author(s)

Pareeta Kotecha, Silvia Perez-Vilar, Joshua Lloyd, Sukhminder K. Sandhu, Ryan Schoeplein, Wenxi Huang, Jordyn Weiner, Crystal Naranjo, Eva Spin, Merial Chatila, Thorben Kurzbach, Shao-Hsuan Chang, Sophia Pliego, Munaza Riaz, Sebastian Jugl, Lauren Adkins, Jingchuan Guo, Yan Wang, Almut G. Winterstein, Amie Goodin 

Corresponding Author

Amie Goodin; Department of Pharmaceutical Outcomes and Policy, University of Florida, FL, United States; Center for Drug Evaluation & Safety (CoDES), FL, United States; Consortium for Medical Marijuana Clinical Outcomes Research, FL, United States

Email: amie.goodin@ufl.edu