Effects of Adjusting for Instrumental Variables on Bias and Precision of Effect Estimates

Project Title	Effects of Adjusting for Instrumental Variables on Bias and Precision of Effect Estimates
Date	Wednesday, June 8, 2011
Location	American Journal of Epidemiology, Volume 174, Issue 11, October 2011, Pages 1213-1222 DOI: 10.1093/aje/kwr364
Description	The authors present results from two simulation studies to provide insight into the problem of conditioning on potential IVs in routine epidemiologic practice. The simulations explored the effects of conditioning on IVs, near IVs (predictors of exposure that are weakly associated with outcome), and confounders on the bias and variance of a binary exposure effect estimate.
Corresponding Author	J. A. Myers, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA. Email: jmyers6@partners.org
Authors	Jessica A. Myers PhD, ScD; Jeremy A. Rassen ScD; Joshua J. Gagne PharmD, MS; Krista F. Huybrechts PhD, MS; Sebastian Schneeweiss MD, ScD; Kenneth J. Rothman MPH, DrPH; Marshall M. Joffe MD, PhD, MPH; Robert J. Glynn PhD, ScD
Related Assessments	Signal Evaluation Methods (Automated)
Publication Type	Publication

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