Conducting Vaccine Effectiveness Surveillance in Sentinel’s PRISM Program

Project Title Conducting Vaccine Effectiveness Surveillance in Sentinel’s PRISM Program
Date Posted
Friday, April 27, 2018
Status
Complete
Deliverables
Description

The purpose of this activity was to develop a White Paper that addresses the suitability of using Sentinel to estimate vaccine effectiveness. The three aims were:

  1. Provide an overview of study designs and methods used to estimate vaccine effectiveness in claims and electronic health data.
  2. Address the strengths and limitations of using Sentinel data and infrastructure to estimate vaccine effectiveness.
  3. If estimating vaccine effectiveness in Sentinel is feasible, the most suitable study design will be selected to implement Sentinel and potential use cases will be provided.
Workgroup Leader(s)

Meghan Baker MD, ScD; Catherine Panozzo MPH, PhD; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

Maria Said MD, MHS; Azadeh Shoaibi MS, MHS; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD

Workgroup Members

Roger Baxter; Bruce Fireman MD; Nicola Klein MD, PhD; Kaiser Permanente Northern California, Vaccine Study Center, Oakland, CA

Elizabeth Dee MPH; Sandra Feibelmann MPH; Hana Lipowicz MPH; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

Kevin Fahey; America’s Health Insurance Plans, Inc., Washington, DC, Department of Population Medicine

Lisa Jackson MD, MPH; Kaiser Washington Health Research Institute, Seattle, WA 

James D. Nordin MD, MPH; HealthPartners Institute for Education and Research, Minneapolis, MN

Deepa Arya MD, MPH, MBA; Richard A. Forshee PhD; Hector S. Izurieta MD, MPH; Yun Lu PhD; David Menschik MD, MPH; Douglas Pratt MD, MPH; Jane Woo MD; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD

Carla V. Rodriguez PhD, MPH; Mid-Atlantic Kaiser Permanente Research Institute, Rockville, MD

Nandini Selvam PhD, MPH, HealthCore Inc, Alexandria, VA

Medical Product
influenza vaccine
Health Outcome
influenza
pneumonia
Time Period
August 1, 2010 - July 31, 2015
Data Sources
Mini-Sentinel Distributed Database (MSDD)