Level 1 Modular Program Queries

Cohort Identification Strategy

Description

Routine Querying Tool

Calculate Background Rates

The program identifies an event (exposure, outcome, condition) and calculates the rate of that event in the Sentinel Distributed Database (SDD). Output includes the number of individuals with the event, eligible members, and eligible member-days. Rates are calculated and reported overall and stratified by requester-defined age group, sex, year, and year-month. An attrition table is provided upon request.

Cohort Identification and Descriptive Analysis (CIDA) Tool

Identify Exposures and Follow-Up Time

The program identifies an exposure of interest, determines exposed time (either requester-defined number of days after treatment initiation or based on drug dispensings’ days supply), and looks for the occurrence of a health outcome of interest (HOI) during exposed time. Output metrics include number of exposure episodes and number of individuals, number of events, and days at-risk. Events per days at-risk are calculated and reported overall and stratified by requester-defined age group, sex, year, and year-month. Incidence rate ratios (IRRs) can be calculated using two identified cohorts (e.g., exposed vs. active-comparator cohort). Unadjusted IRRs and adjusted IRRs (adjusted by age group, sex, year, and Data Partner using Poisson regression) are reported upon request. An attrition table is also provided upon request.

Cohort Identification and Descriptive Analysis (CIDA) Tool

Identify Most Frequently Observed Codes

The program identifies an event (occurrence of an NDC, procedure, and/or diagnosis code) and determines the most frequently observed codes in a requester-defined number of days before and after the event.

Modular Program 7

Evaluate Uptake of New Molecular Entities

The program identifies dispensings of an exposure of interest and characterizes uptake and treatment patterns.

Modular Program 8

Characterize Concomitant Exposures and Follow-Up Time

The program identifies concomitant exposure to two medical products, creates concomitant treatment episodes, and looks for the occurrence of a health outcome of interest (HOI) during exposed time. Concomitant exposure is defined as overlapping exposure to two medical products, with options to add exposure extension periods and to restrict to episodes of a minimum duration. Output metrics include number of treatment episodes and number of patients, number of events, and days at risk. Events per days at risk are calculated.

Modular Program 4