Level 2 Modular Program Queries

Cohort Identification Strategy

Description

Routine Querying Tool

Identify Exposures and Follow-up Time and Perform Propensity Score Matching

This program identifies exposures, follow-up time, outcomes, and covariates, estimates a propensity score (based on predefined covariates and/or via a high-dimensional propensity score approach), and matches patients in an exposed cohort to patients in a comparator cohort based on propensity score. Propensity score estimation and matching is performed within each Sentinel Data Partner site. Treatment effects are estimated using the matched comparisons. Output includes tables of patient characteristics (unmatched and matched cohorts), measures of covariate balance, distribution of propensity score by exposure group, hazard ratios ( with 95% confidence intervals) and incidence rate differences (with 95% confidence intervals).

Cohort Identification and Descriptive Analysis (CIDA) Tool

Self-Controlled Risk Interval Design

This program identifies exposure, defines risk and control windows relative to the exposure date, and examines the occurrence of HOIs during the risk and control windows. Output metrics include number of exposure episodes, exposed individuals, individuals with an HOI in the risk and/or control windows, and censored individuals, overall and stratified by requester-defined age group, sex, year, year-month, and time-to-event (in days). Estimates of relative risk (RR) and 95% confidence intervals are provided.

Cohort Identification and Descriptive Analysis (CIDA) Tool