Concomitant Use of Opioid Analgesics and Cytochrome P450 (CYP) Inhibitors and Inducers

Project Title Concomitant Use of Opioid Analgesics and Cytochrome P450 (CYP) Inhibitors and Inducers
Date Posted
Thursday, February 1, 2018
Project ID
cder_mpl1r_wp055_nsdp_v01
Status
Complete
Deliverables
Description

The goal of this query was to estimate the proportion of incident oxycodone and oxymorphone users concomitantly using a selection of cytochrome P450 (CYP) enzyme inhibitors and inducers in the Sentinel Distributed Database (SDD). Data from January 1, 2013 to December 31, 2016 from 16 health plans contributing to the SDD were included in this report. This request was distributed on June 2, 2017.

Medical Product
CYP inducer
CYP inhibitor
oxycodone
oxymorphone
Population / Cohort
All individuals
Time Period
January 1, 2013 - December 31, 2016
Assessment Type
Safety Analyses
Study Type
Modular Program
Data Sources
Sentinel Distributed Database (SDD)
FDA Center
CDER