Diagnosis of Agranulocytosis Following New Use of Anti-epileptic Drugs, Clozapine, and Olanzapine

Project Title Diagnosis of Agranulocytosis Following New Use of Anti-epileptic Drugs, Clozapine, and Olanzapine
Date Posted
Wednesday, March 21, 2018
Project ID
to09y05_mpr_wp26_v01
Status
Complete
Deliverables
Mini-Sentinel Modular Program Report: Diagnosis of Agranulocytosis Following New Use of AEDs, Clozapine, and Olanzapine, Report 1
Mini-Sentinel Modular Program Report: Diagnosis of Agranulocytosis Following New Use of AEDs, Clozapine, and Olanzapine, Report 2
Description

This report investigated diagnosis of agranulocytosis following new use of several anti-epileptic drugs (AEDs), as well as clozapine and olanzapine. Data from January 1, 2000 to May 31, 2013 from 18 Data Partners contributing to the Mini-Sentinel Distributed Database (MSDD) were included in this request. The request was distributed to Data Partners on April 11, 2014.
Medical Product
carbamazepine
clozapine
lamotrigine
levetiracetam
ofatumumab
olanzapine
topiramate
Health Outcome
agranulocytosis
Population / Cohort
All individuals
Time Period
January 1, 2000 - May 31, 2013
Assessment Type
Exploratory Analyses
Study Type
Modular Program
Data Sources
Mini-Sentinel Distributed Database (MSDD)
FDA Center
CDER