Testing Routine Querying Tools with Known Positive Exposure-Outcome Associations: Gastrointestinal (GI) Bleeding Following New Use of Warfarin Compared with Statins

This statistical methods project is one of four workgroups that used exposure/outcome pairs with known positive associations to test Mini-Sentinel (now Sentinel) routine querying tools. Specifically, these known positive associations tested the Cohort Identification and Descriptive Analysis (CIDA) tool in combination with the Propensity Score Analysis (PSA) tool.

This known positive test case assessed the association between new use of warfarin and gastrointestinal (GI) bleeding, with statins as the comparison exposure. Data from January 1, 2012 to September 30, 2015 from 14 Data Partners contributing to the Sentinel Distributed Database (SDD) were included in this report.