Developing Disease Risk Score Estimation Functional Specification

Project Title Developing Disease Risk Score Estimation Functional Specification
Date Posted
Thursday, June 15, 2017
Status
In progress
Description

The objective of this project is to write a detailed functional specification to perform disease risk score (DRS) estimation in the Sentinel Distributed Database (SDD).

This enhancement will enable options for DRS estimation in three cohorts: (1) the full concurrent cohort (i.e., all patients who contribute to the analysis); (2) comparator patients in the concurrent cohort (i.e., patients in the concurrent cohort exposed to the comparator product); and (3) a historical cohort of patients exposed to the comparator product. 

This specification will include options for DRS development using both Cox proportional hazards regression and logistic regression; various options for the approach to follow-up for patients contributing to the DRS model; and options for inclusion of interaction terms among pre-specified variables. The specification will also include multiple options for using the estimated DRS, including matching, stratification, and inclusion as a covariate in an outcome regression model.

Workgroup Leader(s)

Joshua J. Gagne PharmD, ScD; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA