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Testing Routine Querying Tools with Known Positive Exposure-Outcome Associations: Clostridium difficile Events After Use of Oral Clindamycin versus Penicillins

Basic Details
Date Posted
Tuesday, March 27, 2018
Status
Complete
Medical Product
clindamycin
Health Outcome(s)
clostridium difficile
Description

This statistical methods project is one of four workgroups that used exposure/outcome pairs with known positive associations to test Mini-Sentinel (now Sentinel) routine querying tools. Specifically, these known positive associations tested the Cohort Identification and Descriptive Analysis (CIDA) tool in combination with the Propensity Score Analysis (PSA) tool.

This known positive test case assessed oral clindamycin versus penicillins and risk of clostridium difficile infection. Data from January 1, 2006 to December 31, 2013 from 10 health plans contributing to the Mini-Sentinel Distributed Database (MSDD) were included in this report. This request was distributed on April 2, 2015.

Deliverable(s) (2)
Mini-Sentinel Modular Program Report: Clostridium difficile Events After Use of Oral Clindamycin vs. Penicillins, Report 1 Mini-Sentinel Modular Program Report: Clostridium difficile Events After Use of Oral Clindamycin vs. Penicillins, Report 2
Information
Time Period
January 1, 2006 - December 31, 2013
Population / Cohort
All individuals
Data Source(s)
Mini-Sentinel Distributed Database (MSDD)
Related Links
Related Link(s)
Evaluation of the US Food and Drug Administration Sentinel Analysis Tools in Confirming Previously Observed Drug-Outcome Associations: The Case of Clindamycin and Clostridium difficile Infection
Clostridium difficile Algorithm Defined in "Testing Routine Querying Tools with Known Positive Exposure-Outcome Associations: Clostridium difficile Events After Use of Oral Clindamycin versus Penicillins"
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